hcg receptors การใช้
ประโยค
- Leydig cell hypoplasia is caused by genetic mutations in " LHCGR ", a gene which encodes the LH / hCG receptor.
- LH normally acts through the LH / hCG receptor to stimulate the growth of Leydig cells in the testicles and the production of androgens such as testosterone and dihydrotestosterone ( DHT ) by these cells.
- In Leydig cell hypoplasia however, there is a reduced capacity for the LH / hCG receptor to respond to LH . This results in hypoplasia or absence of Leydig cells, testicular atrophy, and lower than normal androgen levels.
- An in vitro model of early human embryogenesis ( human embryonic stem cells ( hESCs ) ) has demonstrated that hCG promotes cell proliferation via the LH / hCG receptor ( LHCGR ) . hCG signaling upregulates the expression of steroidogenic acute regulatory protein ( StAR )-mediated cholesterol transport and the synthesis of progesterone in hESC . The production of progesterone at this time induces embryroid body ( akin to blastulation ) and rosette ( akin to neurulation ) formation in vitro.